1. Zingiber roseum Rosc. rhizome: A rich source of hepatoprotective polyphenols
- Author
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Muhammed Amanat, Md. Sharif Reza, Md. Sadikur Rahman Shuvo, Khondoker Shahin Ahmed, Hemayet Hossain, Muhammad Tawhid, Md. Saifuzzaman, Mohammad Shariful Islam, Tanoy Mazumder, Md. Amirul Islam, and A F M Shahid Ud Daula
- Subjects
Zingiber roseum ,Phenolic compounds ,Carbon tetrachloride ,Hepatoprotection ,Molecular docking ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Zingiber roseum is native to Bangladesh and widely used in folk medicine. This present study was designed to assess the ameliorative potential of Zingiber roseum rhizome extract in carbon tetrachloride (CCl4) induced hepatotoxicity in mice model. Seven phenolic compounds were identified and quantified by HPLC analysis in the plant extract, including quercetin, myricetin, catechin hydrate, trans-ferulic acid, trans-cinnamic acid, (-) epicatechin, and rosmarinic acid. Hepatotoxicity was induced by administrating a single intraperitoneal injection of CCl4 (10 mL/kg) on 7th day of treatment. The results revealed that plant extract at all doses (100, 200 and 400 mg/kg) significantly reduced (p
- Published
- 2021
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