1. ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
- Author
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Elena Marcello, Monica Di Luca, Miren Ettcheto, Jordi Olloquequi, Silvia Pelucchi, Antoni Camins, Márcia Regina Cominetti, Amanda Cano, Patricia Regina Manzine, Kristina Endres, Oriol Busquets, and Universitat de Barcelona
- Subjects
0301 basic medicine ,Farmacologia ,ADAM10 ,Disease ,RM1-950 ,Natural compounds ,Cleavage (embryo) ,Neuroprotection ,Catechin ,03 medical and health sciences ,ADAM10 Protein ,Amyloid beta-Protein Precursor ,0302 clinical medicine ,Alzheimer Disease ,Disintegrin ,Humans ,Senile plaques ,Pharmacological modulation ,Pharmacology ,Metalloproteinase ,Amyloid beta-Peptides ,biology ,Chemistry ,Plant Extracts ,Proteins ,Ginkgo biloba ,Membrane Proteins ,General Medicine ,α-Secretase ,Alzheimer's disease ,030104 developmental biology ,Malaltia d'Alzheimer ,Neuroprotective Agents ,030220 oncology & carcinogenesis ,Pharmaceutical ,biology.protein ,Therapeutics. Pharmacology ,Amyloid Precursor Protein Secretases ,Neuroscience ,Alzheimer’s disease ,Proteïnes ,Biomarkers - Abstract
Alzheimer’s disease (AD) represents a global burden in the economics of healthcare systems. Amyloid-β (Aβ) peptides are formed by amyloid-β precursor protein (AβPP) cleavage, which can be processed by two pathways. The cleavage by the α-secretase A Disintegrin And Metalloprotease 10 (ADAM10) releases the soluble portion (sAβPPα) and prevents senile plaques. This pathway remains largely unknown and ignored, mainly regarding pharmacological approaches that may act via different signaling cascades and thus stimulate non-amyloidogenic cleavage through ADAM10. This review emphasizes the effects of natural compounds on ADAM10 modulation, which eventuates in a neuroprotective mechanism. Moreover, ADAM10 as an AD biomarker is revised. New treatments and preventive interventions targeting ADAM10 regulation for AD are necessary, considering the wide variety of ADAM10 substrates.
- Published
- 2018