1. Non-Coding RNAs and Innate Immune Responses in Cancer
- Author
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Carlos Romero Díaz, María Teresa Hernández-Huerta, Laura Pérez-Campos Mayoral, Miriam Emily Avendaño Villegas, Edgar Zenteno, Margarito Martínez Cruz, Eduardo Pérez-Campos Mayoral, María del Socorro Pina Canseco, Gabriel Mayoral Andrade, Manuel Ángeles Castellanos, José Manuel Matías Salvador, Eli Cruz Parada, Alexis Martínez Barras, Jaydi Nora Cruz Fernández, Daniel Scott-Algara, and Eduardo Pérez-Campos
- Subjects
cancer ,piRNA ,miRNA ,siRNA ,specificity ,immune-inducible ,Biology (General) ,QH301-705.5 - Abstract
Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), with a focus on cancer, innate immunity, and inflammation. We found that ncRNAs are closely related to innate immunity, epigenetics, chronic inflammation, and cancer and share properties such as inducibility, specificity, memory, and transfer. These similarities and interrelationships suggest that ncRNAs and modulators of trained immunity, together with the control of chronic inflammation, can be combined to develop novel therapeutic approaches for personalized cancer treatment. In conclusion, the close relationship between ncRNAs, the innate immune system, and inflammation highlights their importance in cancer pathways and their potential as targets for novel therapeutic strategies.
- Published
- 2024
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