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1. Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle

Author

Staresinic, Mario, primary, Japjec, Mladen, additional, Vranes, Hrvoje, additional, Prtoric, Andreja, additional, Zizek, Helena, additional, Krezic, Ivan, additional, Gojkovic, Slaven, additional, Smoday, Ivan Maria, additional, Oroz, Katarina, additional, Staresinic, Eva, additional, Dretar, Vilim, additional, Yago, Haidi, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Lovric, Eva, additional, Batelja Vuletic, Lovorka, additional, Simeon, Paris, additional, Dobric, Ivan, additional, Strbe, Sanja, additional, Kokot, Antonio, additional, Vlainic, Josipa, additional, Blagaic, Alenka Boban, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2022
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2. Fourier Transform Infrared Spectroscopy Reveals Molecular Changes in Blood Vessels of Rats Treated with Pentadecapeptide BPC 157

Author

Gamulin, Ozren, primary, Oroz, Katarina, additional, Coric, Luka, additional, Krajacic, Maria, additional, Skrabic, Marko, additional, Dretar, Vilim, additional, Strbe, Sanja, additional, Talapko, Jasminka, additional, Juzbasic, Martina, additional, Krezic, Ivan, additional, Lozic, Marin, additional, Stambolija, Vasilije, additional, Zizek, Helena, additional, Jurca, Ivana, additional, Jurjevic, Ivana, additional, Blagaic, Alenka Boban, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2022
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3. Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation

Author

Sikiric, Predrag, primary, Udovicic, Mario, additional, Barisic, Ivan, additional, Balenovic, Diana, additional, Zivanovic Posilovic, Gordana, additional, Strinic, Dean, additional, Uzun, Sandra, additional, Sikiric, Suncana, additional, Krezic, Ivan, additional, Zizek, Helena, additional, Yago, Haidi, additional, Gojkovic, Slaven, additional, Smoday, Ivan Maria, additional, Kalogjera, Luka, additional, Vranes, Hrvoje, additional, Sola, Marija, additional, Strbe, Sanja, additional, Koprivanac, Antun, additional, Premuzic Mestrovic, Ivica, additional, Mestrovic, Tomislav, additional, Pavic, Predrag, additional, Skrtic, Anita, additional, Blagaic, Alenka Boban, additional, Lovric Bencic, Martina, additional, and Seiwerth, Sven, additional

Published
2022
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4. BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling “Negative-Like” Symptoms of Schizophrenia

Author

Zemba Cilic, Andrea, primary, Zemba, Mladen, additional, Cilic, Matija, additional, Strbe, Sanja, additional, Ilic, Spomenko, additional, Vukojevic, Jaksa, additional, Zoricic, Zoran, additional, Filipcic, Igor, additional, Kokot, Antonio, additional, Smoday, Ivan Maria, additional, Rukavina, Iva, additional, Boban Blagaic, Alenka, additional, Tvrdeic, Ante, additional, Duplancic, Bozidar, additional, Stambolija, Vasilije, additional, Marcinko, Darko, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2022
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5. Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats

Author

Smoday, Ivan Maria, primary, Petrovic, Igor, additional, Kalogjera, Luka, additional, Vranes, Hrvoje, additional, Zizek, Helena, additional, Krezic, Ivan, additional, Gojkovic, Slaven, additional, Skorak, Ivan, additional, Hriberski, Klaudija, additional, Brizic, Ivan, additional, Kubat, Milovan, additional, Strbe, Sanja, additional, Barisic, Ivan, additional, Sola, Marija, additional, Lovric, Eva, additional, Lozic, Marin, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2022
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6. Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats

Author

Barisic, Ivan, primary, Balenovic, Diana, additional, Udovicic, Mario, additional, Bardak, Darija, additional, Strinic, Dean, additional, Vlainić, Josipa, additional, Vranes, Hrvoje, additional, Smoday, Ivan Maria, additional, Krezic, Ivan, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Uzun, Sandra, additional, Zivanovic Posilovic, Gordana, additional, Strbe, Sanja, additional, Vukoja, Ivan, additional, Lovric, Eva, additional, Lozic, Marin, additional, Sever, Marko, additional, Lovric Bencic, Martina, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2022
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7. Stable Gastric Pentadecapeptide BPC 157 Therapy of Rat Glaucoma

Author

Kralj, Tamara, primary, Kokot, Antonio, additional, Zlatar, Mirna, additional, Masnec, Sanja, additional, Kasnik Kovac, Katarina, additional, Milkovic Perisa, Marija, additional, Batelja Vuletic, Lovorka, additional, Giljanovic, Ana, additional, Strbe, Sanja, additional, Sikiric, Suncana, additional, Balog, Slaven, additional, Sontacchi, Bojan, additional, Sontacchi, Dijana, additional, Buljan, Matko, additional, Lovric, Eva, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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8. Stable Gastric Pentadecapeptide BPC 157 as a Therapy for the Disable Myotendinous Junctions in Rats

Author

Japjec, Mladen, primary, Horvat Pavlov, Katarina, additional, Petrovic, Andreja, additional, Staresinic, Mario, additional, Sebecic, Bozidar, additional, Buljan, Matko, additional, Vranes, Hrvoje, additional, Giljanovic, Ana, additional, Drmic, Domagoj, additional, Japjec, Miroslav, additional, Prtoric, Andreja, additional, Lovric, Eva, additional, Batelja Vuletic, Lovorka, additional, Dobric, Ivan, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Predrag, Sikiric, additional

Published
2021
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9. Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157

Author

Strbe, Sanja, primary, Gojkovic, Slaven, additional, Krezic, Ivan, additional, Zizek, Helena, additional, Vranes, Hrvoje, additional, Barisic, Ivan, additional, Strinic, Dean, additional, Orct, Tatjana, additional, Vukojevic, Jaksa, additional, Ilic, Spomenko, additional, Lovric, Eva, additional, Muzinic, Darija, additional, Kolenc, Danijela, additional, Filipčić, Igor, additional, Zoricic, Zoran, additional, Marcinko, Darko, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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10. Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157

Author

Gojkovic, Slaven, primary, Krezic, Ivan, additional, Vranes, Hrvoje, additional, Zizek, Helena, additional, Drmic, Domagoj, additional, Batelja Vuletic, Lovorka, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Stilinovic, Irma, additional, Simeon, Paris, additional, Knezevic, Mario, additional, Kolak, Toni, additional, Tepes, Marijan, additional, Simonji, Karol, additional, Strbe, Sanja, additional, Nikolac Gabaj, Nora, additional, Barisic, Ivan, additional, Oreskovic, Emma Grace, additional, Lovric, Eva, additional, Kokot, Antonio, additional, Skrtic, Anita, additional, Boban Blagaic, Alenka, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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11. Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats

Author

Rasic, Domagoj, primary, Zenko Sever, Anita, additional, Rasic, Fran, additional, Strbe, Sanja, additional, Rasic, Zarko, additional, Djuzel, Antonija, additional, Duplancic, Bozidar, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, Sikiric, Predrag, additional, and Sever, Marko, additional

Published
2021
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12. Intracranial, Portal, and Caval Hypertension

Author

Knezevic, Mario, Gojkovic, Slaven, Krezic, Ivan, Zizek, Helena, Malekinusic, Dominik, Vrdoljak, Borna, Vranes, Hrvoje, Knezevic, Tamara, Barisic, Ivan, Pavlov, Katarina Horvat, Drmic, Domagoj, Staroveski, Miro, Djuzel, Antonija, Rajkovic, Zoran, Kolak, Toni, Kocman, Ivica, Lovric, Eva, Milavic, Marija, Sikiric, Suncana, Tvrdeic, Ante, Patrlj, Leonardo, Strbe, Sanja, Kokot, Antonio, Blagaic, Alenka Boban, Skrtic, Anita, Seiwerth, Sven, and Sikiric, Predrag

Subjects
rats, vascular recruitment, superior mesenteric artery occlusion, BPC 157
Abstract

Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to the abdominal aorta. Previously, when confronted with major vessel occlusion, its effect would rapidly activate collateral vessel pathways and resolve major venous occlusion syndromes (Pringle maneuver ischemia, reperfusion, Budd–Chiari syndrome) in rats. This would overwhelm superior mesenteric artery permanent occlusion, and result in local, peripheral, and central disturbances. Methods: Assessments, for 30 min (gross recording, angiography, ECG, pressure, microscopy, biochemistry, and oxidative stress), included the portal hypertension, caval hypertension, and aortal hypotension, and centrally, the superior sagittal sinus hypertension, systemic arterial and venous thrombosis, ECG disturbances, MDA-tissue increase, and multiple organ lesions and disturbances, including the heart, lung, liver, kidney, and gastrointestinal tract, in particular, as well as brain (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus). BPC 157 therapy (/kg, abdominal bath) (10 µg, 10 ng) was given for a 1-min ligation time. Results: BPC 157 rapidly recruits collateral vessels (inferior anterior pancreaticoduodenal artery and inferior mesenteric artery) that circumvent occlusion and ascertains blood flow distant from the occlusion in the superior mesenteric artery. Portal and caval hypertension, aortal hypotension, and, centrally, superior sagittal sinus hypertension were attenuated or eliminated, and ECG disturbances markedly mitigated. BPC 157 therapy almost annihilated venous and arterial thrombosis. Multiple organ lesions and disturbances (i.e., heart, lung, liver, and gastrointestinal tract, in particular, as well as brain) were largely attenuated. Conclusions: Rats with superior mesenteric artery occlusion may additionally undergo BPC 157 therapy as full counteraction of vascular occlusion-induced multiple organ dysfunction syndrome.

Published
2021
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13. Complex Syndrome of the Complete Occlusion of the End of the Superior Mesenteric Vein, Opposed with the Stable Gastric Pentadecapeptide BPC 157 in Rats

Author

Knezevic, Mario, primary, Gojkovic, Slaven, additional, Krezic, Ivan, additional, Zizek, Helena, additional, Vranes, Hrvoje, additional, Malekinusic, Dominik, additional, Vrdoljak, Borna, additional, Knezevic, Tamara, additional, Horvat Pavlov, Katarina, additional, Drmic, Domagoj, additional, Staroveski, Miro, additional, Djuzel, Antonija, additional, Rajkovic, Zoran, additional, Kolak, Toni, additional, Lovric, Eva, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Barisic, Ivan, additional, Tepes, Marijan, additional, Tvrdeic, Ante, additional, Patrlj, Leonardo, additional, Strbe, Sanja, additional, Sola, Marija, additional, Situm, Andrej, additional, Kokot, Antonio, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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14. Stable Gastric Pentadecapeptide BPC 157 Therapy for Monocrotaline-Induced Pulmonary Hypertension in Rats Leads to Prevention and Reversal

Author

Udovicic, Mario, primary, Sever, Marko, additional, Kavur, Lovro, additional, Loncaric, Kristina, additional, Barisic, Ivan, additional, Balenovic, Diana, additional, Zivanovic Posilovic, Gordana, additional, Strinic, Dean, additional, Uzun, Sandra, additional, Batelja Vuletic, Lovorka, additional, Sikiric, Suncana, additional, Skrtic, Anita, additional, Drmic, Domagoj, additional, Boban Blagaic, Alenka, additional, Lovric Bencic, Martina, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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15. Occluded Superior Mesenteric Artery and Vein. Therapy with the Stable Gastric Pentadecapeptide BPC 157

Author

Knezevic, Mario, primary, Gojkovic, Slaven, additional, Krezic, Ivan, additional, Zizek, Helena, additional, Malekinusic, Dominik, additional, Vrdoljak, Borna, additional, Knezevic, Tamara, additional, Vranes, Hrvoje, additional, Drmic, Domagoj, additional, Staroveski, Miro, additional, Djuzel, Antonija, additional, Rajkovic, Zoran, additional, Kolak, Toni, additional, Lovric, Eva, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Tvrdeic, Ante, additional, Patrlj, Leonardo, additional, Strbe, Sanja, additional, Sola, Marija, additional, Situm, Andrej, additional, Kokot, Antonio, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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16. BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment

Author

Gojkovic, Slaven, primary, Krezic, Ivan, additional, Vranes, Hrvoje, additional, Zizek, Helena, additional, Drmic, Domagoj, additional, Horvat Pavlov, Katarina, additional, Petrovic, Andrea, additional, Batelja Vuletic, Lovorka, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Stilinovic, Irma, additional, Samara, Mariam, additional, Knezevic, Mario, additional, Barisic, Ivan, additional, Sjekavica, Ivica, additional, Lovric, Eva, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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17. Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension

Author

Knezevic, Mario, primary, Gojkovic, Slaven, additional, Krezic, Ivan, additional, Zizek, Helena, additional, Malekinusic, Dominik, additional, Vrdoljak, Borna, additional, Vranes, Hrvoje, additional, Knezevic, Tamara, additional, Barisic, Ivan, additional, Horvat Pavlov, Katarina, additional, Drmic, Domagoj, additional, Staroveski, Miro, additional, Djuzel, Antonija, additional, Rajkovic, Zoran, additional, Kolak, Toni, additional, Kocman, Ivica, additional, Lovric, Eva, additional, Milavic, Marija, additional, Sikiric, Suncana, additional, Tvrdeic, Ante, additional, Patrlj, Leonardo, additional, Strbe, Sanja, additional, Kokot, Antonio, additional, Boban Blagaic, Alenka, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional

Published
2021
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18. Stable Gastric Pentadecapeptide BPC 157 Therapy of Rat Glaucoma.

Author

Kralj, Tamara, Kokot, Antonio, Zlatar, Mirna, Masnec, Sanja, Kasnik Kovac, Katarina, Milkovic Perisa, Marija, Batelja Vuletic, Lovorka, Giljanovic, Ana, Strbe, Sanja, Sikiric, Suncana, Balog, Slaven, Sontacchi, Bojan, Sontacchi, Dijana, Buljan, Matko, Lovric, Eva, Boban Blagaic, Alenka, Skrtic, Anita, Seiwerth, Sven, and Sikiric, Predrag

Subjects
OPEN-angle glaucoma, RETINAL blood vessels, OPTIC disc, PUPILLOMETRY, RETINAL ganglion cells, TRABECULECTOMY, OPTIC nerve, INTRAOCULAR pressure
Abstract

Cauterization of three episcleral veins (open-angle glaucoma model) induces venous congestion and increases intraocular pressure in rats. If not upgraded, one episcleral vein is regularly unable to acquire and take over the whole function, and glaucoma-like features persist. Recently, the rapid upgrading of the collateral pathways by a stable gastric pentadecapeptide BPC 157 has cured many severe syndromes induced by permanent occlusion of major vessels, veins and/or arteries, peripherally and centrally. In a six-week study, medication was given prophylactically (immediately before glaucoma surgery, i.e., three episcleral veins cauterization) or as curative treatment (starting at 24 h after glaucoma surgery). The daily regimen of BPC 157 (0.4 µg/eye, 0.4 ng/eye; 10 µg/kg, 10 ng/kg) was administered locally as drops in each eye, intraperitoneally (last application at 24 h before sacrifice) or per-orally in drinking water (0.16 µg/mL, 0.16 ng/mL, 12 mL/rat until the sacrifice, first application being intragastric). Consequently, all BPC 157 regimens immediately normalized intraocular pressure. BPC 157-treated rats exhibited normal pupil diameter, microscopically well-preserved ganglion cells and optic nerve presentation, normal fundus presentation, normal retinal and choroidal blood vessel presentation and normal optic nerve presentation. As leading symptoms, increased intraocular pressure and mydriasis, as well as degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels and severe optic nerve disc atrophy were all counteracted. In conclusion, we claim that the reversal of the episcleral veins cauterization glaucoma appeared as a consequence of the BPC 157 therapy of the vessel occlusion-induced perilous syndrome. [ABSTRACT FROM AUTHOR]

Published
2022
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