1. Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats
- Author
-
Stephen M. Suru
- Subjects
Male ,Pharmacology ,Kidney ,medicine.disease_cause ,Antioxidants ,General Biochemistry, Genetics and Molecular Biology ,Nephrotoxicity ,Biomaterials ,Lipid peroxidation ,Superoxide dismutase ,chemistry.chemical_compound ,Malondialdehyde ,Onions ,Cadmium Compounds ,medicine ,Animals ,Rats, Wistar ,Garlic ,biology ,Plant Extracts ,Sulfates ,Superoxide Dismutase ,Body Weight ,Metals and Alloys ,food and beverages ,Glutathione ,Catalase ,Allium sativum ,biology.organism_classification ,Rats ,medicine.anatomical_structure ,Biochemistry ,chemistry ,biology.protein ,Allium ,Kidney Diseases ,General Agricultural and Biological Sciences ,Oxidative stress - Abstract
Cadmium (Cd) is a well-known nephrotoxicant inducing kidney damage via oxidative stress. Since kidney is the critical target organ of Cd toxicity, this study was designed to evaluate the protective effects of onion (Allium cepa L.) and garlic (Allium sativum L.) aqueous extracts on Cd-induced renal oxidative stress in male Wistar rats. The control group received double distilled water alone and Cd group was challenged with 3CdSO4 · 8H2O (as Cd) (1.5 mg/100 g bw/day per oral) alone. Extract-treated groups were pre-treated with varied doses (0.5 ml and 1.0 ml/100 g bw/day per oral) of onion and/or garlic extract for 1 week after which they were co-treated with Cd (1.5 mg/100 g bw/day per oral) for 3 weeks. The results showed that the levels of renal lipid peroxidation (LPO) and glutathione-S transferase (GST) were significantly (P
- Published
- 2008