1. Myosteatosis in NAFLD patients correlates with plasma Cathepsin D
- Author
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Lingling Ding, Inês Magro dos Reis, Ronit Shiri-Sverdlov, Jef Verbeek, Yvonne Oligschlaeger, Tom Houben, Ger H. Koek, Toon. J. I. De Munck, Molecular Genetics, RS: NUTRIM - R2 - Liver and digestive health, Interne Geneeskunde, and MUMC+: MA Maag Darm Lever (9)
- Subjects
Male ,0301 basic medicine ,Sarcopenia ,Cathepsin D ,nafld ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,Nonalcoholic fatty liver disease ,steatosis ,Biology (General) ,ectopic lipid accumulation ,plasma ctsd levels ,General Medicine ,Middle Aged ,medicine.anatomical_structure ,Cathepsin D/blood ,Muscle ,Female ,medicine.symptom ,Plasma CTSD levels ,Adult ,medicine.medical_specialty ,Fibrosis/blood ,Lipid accumulation ,QH301-705.5 ,Inflammation ,Skeletal/metabolism ,General Biochemistry, Genetics and Molecular Biology ,Young Adult ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Disease severity ,NAFLD ,myosteatosis ,Internal medicine ,medicine ,Humans ,Secretion ,Muscle, Skeletal ,Aged ,Muscle, Skeletal/metabolism ,business.industry ,Skeletal muscle ,medicine.disease ,Fibrosis ,030104 developmental biology ,Endocrinology ,Non-alcoholic Fatty Liver Disease/physiopathology ,Sarcopenia/blood ,Steatosis ,business ,030217 neurology & neurosurgery - Abstract
Previously, we have shown that hepatic lipid accumulation induces the secretion of cathepsin D (CTSD), and that plasma CTSD levels are associated with increased inflammation and disease severity in nonalcoholic fatty liver disease (NAFLD). Although it is clear that the liver is a major source of plasma CTSD, it is unknown whether other metabolically active organs such as the muscle, also associate with plasma CTSD levels in NAFLD patients. Therefore, the aim of this study was to explore the relation between lipid accumulation in the muscle (myosteatosis) and plasma CTSD levels in forty-five NAFLD patients. We observed that hepatic steatosis positively associated with plasma CTSD levels, confirming the previously established link between plasma CTSD and the liver. Furthermore, a positive association between myosteatosis and plasma CTSD levels was observed, which was independent of sex, age, BMI, waist circumference and hepatic steatosis. By establishing a positive association between myosteatosis and plasma CTSD levels, our findings suggest that, in addition to the liver, the muscle is also linked to plasma CTSD levels in NAFLD patients. The observed link between myosteatosis and plasma CTSD levels supports the concept of a significant role of the skeletal muscle in metabolic disturbances in metabolic syndrome-related disorders. ispartof: Biomol Concepts vol:12 issue:1 pages:27-35 ispartof: location:Germany status: Published online
- Published
- 2021
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