1. Identification of novel ASK1 inhibitors using virtual screening
- Author
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Okamoto, Masako, Saito, Nae, Kojima, Hirotatsu, Okabe, Takayoshi, Takeda, Kohsuke, Ichijo, Hidenori, Furuya, Toshio, and Nagano, Tetsuo
- Subjects
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MITOGEN-activated protein kinases , *APOPTOSIS , *CHEMICAL libraries , *TARGETED drug delivery , *ANTINEOPLASTIC agents , *CARDIOVASCULAR diseases , *DRUG use testing , *ENZYME inhibitors , *INFLAMMATION - Abstract
Abstract: Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. We identified novel ASK1 inhibitors by virtual screening from the public chemical library collected by Chemical Biology Research Initiative (CBRI) at the University of Tokyo. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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