1. Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates
- Author
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Coleen Holewa, Graham B. Jones, Amy E. Kallmerten, Paul J. LaBeaume, Danielle Falcone, Krista M. Wager, Jane Li, Vladimir P. Torchilin, and Curtis Castro
- Subjects
Photosensitizing Agents ,Bioconjugation ,Chemistry ,Organic Chemistry ,Clinical Biochemistry ,Metal Nanoparticles ,Pharmaceutical Science ,Antineoplastic Agents ,Conjugated system ,Biochemistry ,Chemical synthesis ,Antibodies ,Polyethylene Glycols ,Immunoconjugate ,Drug Discovery ,Enediyne ,Molecular Medicine ,Organic chemistry ,Surface modification ,Gold ,Enediynes ,Molecular Biology ,Nanoconjugates ,Conjugate - Abstract
Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.
- Published
- 2009
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