Search

Your search keyword '"Chao, Mei"' showing total 5 results
Start Over Author "Chao, Mei" Journal bioorganic & medicinal chemistry
5 results on '"Chao, Mei"'

5. Synthesis of chlorogenic acid derivatives with promising antifungal activity

Author

Maureen Kully, Jehangir K. Khan, Chao-Mei Ma, Mohsen Daneshtalab, and Masao Hattori

Subjects
Antifungal Agents, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Aspergillus fumigatus, chemistry.chemical_compound, Chlorogenic acid, Echinocandin B, Drug Discovery, medicine, Molecular Biology, Candida, Cryptococcus neoformans, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Quinic acid, Phenolic acid, biology.organism_classification, Amino acid, Molecular Medicine, Chlorogenic Acid
Abstract

Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results