1. Correlating the structure and reactivity of a contact allergen, DNCB, and its analogs to sensitization potential
- Author
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Aaron P. Esser-Kahn, Seong Min Kim, Flora W. Kimani, and Rachel C. Steinhardt
- Subjects
Chemical structure ,Clinical Biochemistry ,Pharmaceutical Science ,Inflammation ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,Article ,Allergen ,Drug Discovery ,Dinitrochlorobenzene ,medicine ,Reactivity (chemistry) ,Molecular Biology ,Sensitization ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Skin sensitization ,Contact hypersensitivity ,Biological activity ,Allergens ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,medicine.anatomical_structure ,Immunology ,Molecular Medicine ,medicine.symptom - Abstract
We report a study that seeks to find a correlation between the overall sensitization potential quantified by the expression of IL-8 by stimulated monocytes and the chemical structure of a model contact allergen, 2,4-dinitrochlorobenzene (DNCB). We show that structure and reactivity of the chemical compounds play an important role in activation of the monocytes and subsequent inflammation in tissue. However, we observed a non-linear correlation between the rate of reaction and biological activity indicating a required balance of stability and reactivity.
- Published
- 2019