Wang, Fa-Zuo, Huang, Zhi, Shi, Xue-Feng, Chen, Yu-Chan, Zhang, Wei-Min, Tian, Xin-Peng, Li, Jie, and Zhang, Si
Abstract: Two new indole diketopiperazines, namely luteoalbusins A–B (1–2), along with eight known ones (3–10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1–5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin. [Copyright &y& Elsevier]