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1. Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity

Author

Mandal, Madhumita, Kumar, Deepak, Roy, Rajneeta, Sen, Rupashree, Das, Padma, Chatterjee, Mitali, and Jaisankar, Parasuraman

Subjects
*ORGANIC synthesis, *ETHYLENE, *CELL-mediated cytotoxicity, *FRIEDEL-Crafts reaction, *ACYLATION, *INDOLE, *LEWIS acids, *CELL lines
Abstract

Abstract: 2,2′-Diphenyl-3,3′-diindolylethylene (DPDIE) derivatives 3a–g were regioselectively prepared in one pot from indoles 1a–g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC50 of 13.0–17.0μM. [Copyright &y& Elsevier]

Published
2011
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