1. Synthesis and cytotoxic activities of semisynthetic zearalenone analogues
- Author
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Benyapa Kaewmee, Kwanruthai Tadpetch, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kawalee Kantee, and Kittisak Chantakaew
- Subjects
Clinical Biochemistry ,Pharmaceutical Science ,Antineoplastic Agents ,01 natural sciences ,Biochemistry ,KB Cells ,Structure-Activity Relationship ,chemistry.chemical_compound ,Chlorocebus aethiops ,Drug Discovery ,Animals ,Humans ,Cytotoxic T cell ,Structure–activity relationship ,Cytotoxicity ,Vero Cells ,Molecular Biology ,Zearalenone ,Cell Proliferation ,Dose-Response Relationship, Drug ,Molecular Structure ,010405 organic chemistry ,Cell growth ,Organic Chemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Epidermoid carcinoma ,Cell culture ,MCF-7 Cells ,Vero cell ,Molecular Medicine ,Drug Screening Assays, Antitumor - Abstract
Zearalenone is a β-resorcylic acid macrolide with various biological activities. Herein we report the synthesis and cytotoxic activities of 34 zearalenone analogues against human oral epidermoid carcinoma (KB) and human breast adenocarcinoma (MCF-7) cells as well as noncancerous Vero cells. Some zearalenone analogues showed moderately enhanced cytotoxic activities against the two cancer cell lines. We have discovered the potential lead compounds with diminished or no cytotoxicity to Vero cells. Preliminary structure-activity relationship studies revealed that the double bond at the 1' and 2' positions of zearalenone core was crucial for cytotoxic activities on both cell lines. In addition, for zearalenol analogues, the unprotected hydroxyl group at C-2 and an alkoxy substituent at C-4 played key roles on cytotoxic effects of both cell lines.
- Published
- 2016