1. 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
- Author
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Siu, Michael, Pastor, Richard, Liu, Wendy, Barrett, Kathy, Berry, Megan, Blair, Wade S., Chang, Christine, Chen, Jacob Z., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, He, Haiying, Hurley, Christopher A., Kenny, Jane R., Cyrus Khojasteh, S., Le, Hoa, Lee, Leslie, Lyssikatos, Joseph P., Magnuson, Steve, and Pulk, Rebecca
- Subjects
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AMINO group , *PYRIDINE , *KINASE inhibitors , *XENOGRAFTS , *LABORATORY mice - Abstract
Abstract: The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed. Display Omitted [Copyright &y& Elsevier]
- Published
- 2013
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