1. Identification of Hsp70 modulators through modeling of the substrate binding domain
- Author
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Barbara Beck, Conor M. Haney, Alexander Dömling, Jeffrey L. Brodsky, and Corinne Schneider
- Subjects
Clinical Biochemistry ,Pharmaceutical Science ,Peptide binding ,Peptide ,Computational biology ,Crystallography, X-Ray ,Biochemistry ,Chemical synthesis ,Article ,Protein–protein interaction ,Heat shock protein ,Drug Discovery ,Computer Simulation ,HSP70 Heat-Shock Proteins ,Amino Acid Sequence ,Binding site ,Molecular Biology ,chemistry.chemical_classification ,Binding Sites ,biology ,Chemistry ,Organic Chemistry ,Protein Structure, Tertiary ,Hsp70 ,Models, Chemical ,Chaperone (protein) ,biology.protein ,Molecular Medicine ,Peptides ,Protein Binding - Abstract
The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology.
- Published
- 2009
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