1. Synthesis and anti-proliferation activity of mogrol derivatives bearing quinoline and triazole moieties
- Author
-
Na Li, Jing-Ru Song, and Dian-Peng Li
- Subjects
Clinical Biochemistry ,Pharmaceutical Science ,Antineoplastic Agents ,Apoptosis ,01 natural sciences ,Biochemistry ,Structure-Activity Relationship ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,medicine ,Humans ,Cytotoxicity ,STAT3 ,Molecular Biology ,Cell Proliferation ,A549 cell ,Dose-Response Relationship, Drug ,Molecular Structure ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Quinoline ,Cancer ,Cell Cycle Checkpoints ,Triazoles ,Cell cycle ,medicine.disease ,In vitro ,respiratory tract diseases ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Quinolines ,biology.protein ,Molecular Medicine ,Drug Screening Assays, Antitumor - Abstract
A series of novel derivatives based on mogrol were designed and synthesized in attempt to improve anti-lung cancer activity. The cytotoxicity against human lung cancer cells including A549 and NCI-H460 were performed by Cell Counting Kit-8 (CCK8) assay in vitro. The screening result showed that compound 8f exhibited the strongest activity with an IC50 value of 4.47 μM against A549 cell, and could induce the cell apoptosis in a dose-dependent manner and arrest cell cycle at G0/G1 phase. Besides, compound 8f displayed anti-proliferation effect on A549 cell through inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3). Furthermore, compared with morgol, compound 10a significantly improved the cytotoxicity against NCI-H460 with the IC50 value of 17.13 μM. The research stimulated the development of potential therapeutic agent for lung cancer from the natural mogrol.
- Published
- 2021