1. Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives
- Author
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Luc Morin-Allory, Bruno Pfeiffer, M.‐C. Viaud, Christophe Marot, G. Guillaumet, Marie-Claire Rettori, Corinne Comoy, Institut de Chimie Organique et Analytique (ICOA), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Orléans (UO)-Institut de Chimie du CNRS (INC), Institut de recherches Servier (INSTITUT DE RECHERCHES SERVIER), and INSTITUT SERVIER
- Subjects
0303 health sciences ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,010405 organic chemistry ,Stereochemistry ,Organic Chemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Quantitative structure ,Biological activity ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,3. Good health ,Benzopyran ,03 medical and health sciences ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Molecular Medicine ,Receptor ,Molecular Biology ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology - Abstract
Synthesis of N -substituted-3,4-dihydro-2 H -1-benzopyran derivatives which have a potential affinity for the 5-HT 1A receptor is reported. The comparison between the experimental values of binding and the prediction of Q.S.A.R. studies is described.
- Published
- 1996