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Your search keyword '"Kamlesh R. Chauhan"' showing total 2 results
Start Over Author "Kamlesh R. Chauhan" Journal bioorganic & medicinal chemistry letters
2 results on '"Kamlesh R. Chauhan"'

1. Eicosanoid biosynthesis: differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase

Author

K. Kishta Reddy, Komandla Malla Reddy, Shozou Wei, John R. Falck, Kamlesh R. Chauhan, Jorge H. Capdevila, Yuri Belosludtsev, and M.Fiona Shortt

Subjects
chemistry.chemical_classification, Epoxygenase, biology, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Cytochrome P450, Biological activity, Biochemistry, chemistry.chemical_compound, Enzyme, chemistry, Enzyme inhibitor, Oxidoreductase, Drug Discovery, biology.protein, Microsome, Molecular Medicine, Arachidonic acid, Molecular Biology
Abstract

Biphenyl 4 and vinyldibromide 8 were prepared on a multigram scale and shown to be comparatively specific arachidonic acid epoxygenase and ω-hydroxylase inhibitors, respectively, in rat kidney microsomal fractions.

Published
1997
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2. Vasoactive eicosanoids: Synthesis of 12,20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)-tetraenoic acid via a novel chiral bis-lactol

Author

William B. Campbell, John R. Falck, Mark Rosolowsky, and Kamlesh R. Chauhan

Subjects
Lactol, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Vasodilation, Biochemistry, chemistry.chemical_compound, Type iib, chemistry, Vasoactive, Drug Discovery, Molecular Medicine, Molecular Biology
Abstract

The type IIB eicosanoids, 12(R),20- and 12(S),20-dihydroxyeicosatetraenoic acid (DiHETE), were conveniently synthesized utilizing a carbohydrate-derived bis-lactol as a differentiated 4-hydroxyhex-2(E)-enedial chiron. 12(S),20-DiHETE, but not the 12(R)-isomer, induced vasodilation in precontracted canine arteries.

Published
1994
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