19 results on '"Thomas, Andrew"'
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2. Imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepines as potent and highly selective GABA A α5 inverse agonists with potential for the treatment of cognitive dysfunction
3. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABA A α5 inverse agonists for the treatment of cognitive dysfunction
4. Discovery of the imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA A α5 inverse agonist series
5. Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors
6. Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors
7. Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
8. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction
9. Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA α5 inverse agonists with potential for the treatment of cognitive dysfunction
10. Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors
11. 4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters
12. Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability
13. Imidazo[1,2- b ]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors
14. Imidazo[1,2- a ]pyridines. Part 2 : SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors
15. Imidazo[1,2-a]pyridines: A potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation
16. A concise route to triazolobenzodiazepine derivatives via a one-Pot alkyne-Azide cycloaddition reaction
17. Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors
18. Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors
19. The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group
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