231 results on '"Wexler, Ruth R."'
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2. Design and preparation of N-linked hydroxypyridine-based APJ agonists
3. Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists
4. Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO)
5. Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies
6. Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors
7. Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ
8. Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa
9. Benzothiazole-based compounds as potent endothelial lipase inhibitors
10. Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability
11. Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase
12. Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors
13. Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]
14. Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
15. Macrocyclic factor XIa inhibitors
16. Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency
17. Neutral macrocyclic factor VIIa inhibitors
18. Synthesis and P1′ SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors
19. Novel phenylalanine derived diamides as Factor XIa inhibitors
20. Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa
21. Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors
22. Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate
23. Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors
24. Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties
25. Pyridine and pyridinone-based factor XIa inhibitors
26. Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties
27. Design, synthesis and evaluation of phenethylaminoheterocycles as Kv1.5 inhibitors
28. 2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists
29. Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent
30. Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors
31. Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds
32. Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors
33. 2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents
34. New azole antagonists with high affinity for the P2Y1 receptor
35. Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility
36. Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor
37. Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors
38. Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors
39. Phenyltriazolinones as potent factor Xa inhibitors
40. Highly efficacious factor Xa inhibitors containing α-substituted phenylcycloalkyl P4 moieties
41. Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors
42. Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa
43. Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties
44. Sulfonamidolactam inhibitors of coagulation factor Xa
45. SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
46. Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors
47. Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications
48. Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
49. Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues
50. Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties
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