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Start Over Author "Zou, Ge" Journal bioorganic & medicinal chemistry letters
3 results on '"Zou, Ge"'

3. Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors

Author

Zhu Wei, Liu Yafei, Xingchun Han, Hong C. Shen, Wang Xiaoqing, Haixia Liu, and Zou Ge

Subjects
Endosome, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Autoimmune Diseases, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Inflammation, Innate immune system, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Inflammasome, DNA, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Immunology, Nucleic acid, RNA, Molecular Medicine, medicine.drug
Abstract

Nucleic acid sensing pathways play an important role in the innate immune system, protecting hosts against infections. However, a large body of evidence supports a close association between aberrant activation of those pathways and autoimmune and inflammatory diseases. Part II of the digest series on small molecule approaches to autoimmune and inflammatory diseases concentrates on recent advances with respect to small molecule antagonists or inhibitors of the nucleic acid sensing pathways, including endosomal TLRs, NLRP3 inflammasome and cGAS-STING.

Published
2021

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