1. 1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors.
- Author
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Deev SL, Yasko MV, Karpenko IL, Korovina AN, Khandazhinskaya AL, Andronova VL, Galegov GA, Shestakova TS, Ulomskii EN, Rusinov VL, Chupakhin ON, and Kukhanova MK
- Subjects
- Animals, Cell Line, Cell Survival, Chlorocebus aethiops, DNA-Directed DNA Polymerase metabolism, Herpesvirus 1, Human enzymology, Humans, Models, Molecular, Nucleic Acid Synthesis Inhibitors, Polyphosphates chemistry, Polyphosphates pharmacology, Vero Cells, Virus Replication drug effects, Antiviral Agents chemistry, Antiviral Agents pharmacology, Herpes Simplex drug therapy, Herpesvirus 1, Human drug effects, Triazines chemistry, Triazines pharmacology, Triazoles chemistry, Triazoles pharmacology
- Abstract
A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo[5,1-c][1,2,4]triazines and 1,2,4-triazolo[1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antiherpetic activity and cytotoxicity of the compounds were studied. The corresponding triphosphates of several active compounds were prepared and tested as inhibitors of DNA synthesis catalyzed by herpes simplex virus polymerase. The potential mechanism of their action is blocking of DNA dependent DNA polymerase, a key enzyme of viral replication., (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
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