1. Isolation and biological activity of azocine and azocane alkaloids.
- Author
-
Lee S and Sperry J
- Subjects
- Alkaloids chemistry, Alkaloids isolation & purification, Anti-Infective Agents chemistry, Anti-Infective Agents isolation & purification, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents isolation & purification, Antimalarials chemistry, Antimalarials isolation & purification, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Azabicyclo Compounds chemistry, Azabicyclo Compounds isolation & purification, Azabicyclo Compounds pharmacology, Azocines chemistry, Azocines isolation & purification, Azocines pharmacology, Humans, Insecticides chemistry, Insecticides isolation & purification, Molecular Structure, Alkaloids pharmacology, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents pharmacology, Antimalarials pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Insecticides pharmacology
- Abstract
Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF