1. Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents.
- Author
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Zhang X, Khalidi O, Kim SY, Wang R, Schultz V, Cress BF, Gross RA, Koffas MAG, and Linhardt RJ
- Subjects
- Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Cell Proliferation drug effects, Cell Survival drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Flavanones chemical synthesis, Flavanones chemistry, Hep G2 Cells, Humans, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Antineoplastic Agents pharmacology, Flavanones pharmacology, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Saccharomyces cerevisiae drug effects
- Abstract
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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