1. Photodynamic effect of meso-(aryl)porphyrins and meso-(1-methyl-4-pyridinium)porphyrins on HaCaT keratinocytes.
- Author
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Slomp AM, Barreira SMW, Carrenho LZB, Vandresen CC, Zattoni IF, Ló SMS, Dallagnol JCC, Ducatti DRB, Orsato A, Duarte MER, Noseda MD, Otuki MF, and Gonçalves AG
- Subjects
- Cell Line, Humans, Keratinocytes cytology, Light, Photosensitizing Agents chemical synthesis, Porphyrins chemical synthesis, Psoriasis drug therapy, Pyridinium Compounds chemical synthesis, Keratinocytes drug effects, Photosensitizing Agents pharmacology, Porphyrins pharmacology, Pyridinium Compounds pharmacology
- Abstract
Sixteen porphyrins, including neutral, anionic and cationic meso-(aryl)porphyrins and meso-(1-methyl-4-pyridinium)porphyrins were herein evaluated in terms of their photosensitizing properties against HaCaT keratinocytes. After an initial screening, the cationic porphyrins were studied in more details, by both determining their log P
OW and performing PDT assays in lower porphyrin concentrations. Porphyrins presenting two or more adjacent positively charged groups, directly linked to the macrocycle meso positions, appeared to be the most effective photosensitizers. The present study also included the dicationic 5,10-diphenyl-15,20-di(1-methylpyridinium-4-yl)porphyrin (14b), which has previously shown promising results on a psoriasis-like in vivo model. Overall results indicated that the beneficial effect related to porphyrins on psoriasis can be related to the decreasing of keratinocyte viability. Furthermore, some of the cationic porphyrins studied appeared as candidates to be utilized as photosensitizers for psoriasis treatment., (Copyright © 2016 Elsevier Ltd. All rights reserved.)- Published
- 2017
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