1. Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies.
- Author
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Thermos K, Froudakis GE, Tagmatarchis N, and Katerinopoulos HE
- Subjects
- Animals, Cell Membrane metabolism, Dopamine Agents chemical synthesis, Models, Theoretical, Prazosin metabolism, Rats, Receptors, Adrenergic, alpha chemistry, Receptors, Adrenergic, alpha-2 chemistry, Spiperone metabolism, Dopamine Agents pharmacology, Quinolines chemistry, Quinolines pharmacology, Receptors, Adrenergic, alpha drug effects, Receptors, Adrenergic, alpha-2 drug effects
- Abstract
In vitro assays on a series of cis- and trans-octahydrobenzo[g]quinolines indicated an unusual trend of affinities at the dopaminergic receptors and alpha adrenoceptors. The trans N-benzyl analogues exhibited affinity at the alpha2 as well as the D1-like receptors whereas their N-unsubstituted congeners showed a distinct preference for the alpha2 adrenoceptor. Enhanced activity for the alpha2 receptors was also exhibited by the cis N-benzylated isomers. These observations are interpreted by theoretical calculations.
- Published
- 2001
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