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Your search keyword '"Ray JE"' showing total 2 results
Start Over Author "Ray JE" Journal bioorganic medicinal chemistry letters
2 results on '"Ray JE"'

1. Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors.

Author

Al-awar RS, Ray JE, Hecker KA, Joseph S, Huang J, Shih C, Brooks HB, Spencer CD, Watkins SA, Schultz RM, Considine EL, Faul MM, Sullivan KA, Kolis SP, Carr MA, and Zhang F

Subjects
Aza Compounds pharmacology, Binding Sites, CDC2-CDC28 Kinases chemistry, Cell Cycle drug effects, Cyclin-Dependent Kinase 2, Enzyme Inhibitors pharmacology, Indoles pharmacology, Models, Molecular, Molecular Structure, Structure-Activity Relationship, Aza Compounds chemical synthesis, CDC2-CDC28 Kinases antagonists & inhibitors, Enzyme Inhibitors chemical synthesis, Indoles chemical synthesis
Abstract

The synthesis of novel aza-1,7-annulated indoles was achieved and these were converted to indolocarbazoles that proved to be potent kinase inhibitors. These compounds were also evaluated in a human colon carcinoma cell line and proved to be good antiproliferative agents.

Published
2004
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2. 1,7-annulated indolocarbazoles as cyclin-dependent kinase inhibitors.

Author

Al-awar RS, Ray JE, Hecker KA, Huang J, Waid PP, Shih C, Brooks HB, Spencer CD, Watkins SA, Patel BR, Stamm NB, Ogg CA, Schultz RM, Considine EL, Faul MM, Sullivan KA, Kolis SP, Grutsch JL, and Joseph S

Subjects
Carbazoles pharmacology, Cyclin D1 antagonists & inhibitors, Cyclin D1 metabolism, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases metabolism, Indoles pharmacology, Protein Kinase Inhibitors pharmacology, Proto-Oncogene Proteins antagonists & inhibitors, Proto-Oncogene Proteins metabolism, Carbazoles chemistry, Cyclin-Dependent Kinases antagonists & inhibitors, Indoles chemistry, Protein Kinase Inhibitors chemistry
Abstract

The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.

Published
2004
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