1. Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.
- Author
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Ling L, Urichuk LJ, Sloley BD, Coutts RT, Baker GB, Shan JJ, and Pang PK
- Subjects
- Animals, Hippocampus drug effects, Hippocampus metabolism, Mice, Monoamine Oxidase Inhibitors chemical synthesis, Monoamine Oxidase Inhibitors chemistry, Neuroprotective Agents chemistry, Norepinephrine metabolism, Phenelzine analogs & derivatives, Phenelzine chemistry, Phenelzine pharmacology, Neuroprotective Agents chemical synthesis, Phenelzine chemical synthesis
- Abstract
A series of N(1)- and N(2)-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N(1)- and N(2)-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
- Published
- 2001
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