1. An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
- Author
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Saruul E, Murata T, Selenge E, Sasaki K, Yoshizaki F, and Batkhuu J
- Subjects
- Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Diterpenes isolation & purification, Diterpenes pharmacology, Gram-Positive Bacteria drug effects, Lamiaceae metabolism, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Conformation, Plant Roots chemistry, Plant Roots metabolism, Plants, Medicinal chemistry, Plants, Medicinal metabolism, Quinones chemistry, Anti-Bacterial Agents chemistry, Diterpenes chemistry, Lamiaceae chemistry
- Abstract
To identify antibacterial components in traditional Mongolian medicinal plant Caryopteris mongolica, an ortho-quinone abietane caryopteron A (1) and three its derivatives caryopteron B-D (2-4) were isolated from the roots of the plant together with three known abietanes demethylcryptojaponol (5), 6α-hydroxydemethyl cryptojaponol (6), and 14-deoxycoleon U (7). The chemical structures of these abietane derivatives were elucidated on the basis of spectroscopic data. Compounds 1-4 had C-13 methylcyclopropane substructures, and 2-4 had a hexanedioic anhydride ring C instead of ortho-quinone in 1. The stereochemistry of these compound was assumed from NOE spectra and ECD Cotton effects. Compounds 1 and 5-7 showed antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Micrococcus luteus, being 1 the more potent., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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