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Your search keyword '"Bing Yu Luh"' showing total 2 results
Start Over Author "Bing Yu Luh" Journal bioorganicmedicinal chemistry
2 results on '"Bing Yu Luh"'

1. Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives

Author

Dane M, Springer, Bing Yu, Luh, Jason, Goodrich, and Joanne J, Bronson

Subjects
Lethal Dose 50, Disease Models, Animal, Mice, Staphylococcus aureus, Structure-Activity Relationship, Cinnamates, Toxicity Tests, Acute, Animals, Methicillin Resistance, Microbial Sensitivity Tests, Staphylococcal Infections, Anti-Bacterial Agents, Cephalosporins
Abstract

Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC(90) against MRSA of 1.0 microg/mL, and a PD(50) of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.

Published
2002

2. Anti-MRSA cephems. Part 3: additional C-7 acid derivatives

Author

Dane M, Springer, Bing Yu, Luh, Jason T, Goodrich, and Joanne J, Bronson

Subjects
Lethal Dose 50, Disease Models, Animal, Mice, Staphylococcus aureus, Structure-Activity Relationship, Animals, Methicillin Resistance, Microbial Sensitivity Tests, Staphylococcal Infections, Anti-Bacterial Agents, Cephalosporins
Abstract

Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting compound (6) displayed an MIC(90) against MRSA of 3.7 microg/mL, and an average PD(50) of 3.9 mg/kg.

Published
2002

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