1. Synthesis and in vitro characterization of platinum(II) anticancer coordinates using FTIR spectroscopy and NCI COMPARE: A fast method for new compound discovery
- Author
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Allison Derenne, Hélène Leclercqz, Michel Gelbcke, Jean Neve, François Dufrasne, Gilles Berger, Véronique Mathieu, and Erik Goormaghtigh
- Subjects
Organoplatinum Compounds ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,chemistry.chemical_element ,Antineoplastic Agents ,Apoptosis ,Biochemistry ,Structure-Activity Relationship ,Cell Line, Tumor ,Drug Discovery ,Spectroscopy, Fourier Transform Infrared ,medicine ,Humans ,Fourier transform infrared spectroscopy ,Cytotoxicity ,Molecular Biology ,Cell Proliferation ,Cisplatin ,Dose-Response Relationship, Drug ,Molecular Structure ,Organic Chemistry ,Cell Cycle ,Flow Cytometry ,Combinatorial chemistry ,In vitro ,chemistry ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Platinum ,medicine.drug - Abstract
Platinum-based drugs have been used for several decades to treat various cancers successfully. Cisplatin is the original compound in this class; it cross-links DNA, resulting in cell cycle arrest and cell death via apoptosis. Cisplatin is effective against several tumor types but exhibits toxic side effects; in addition, tumors often develop resistance. An original in vitro approach is proposed to determine whether platinum-based research compounds are good candidates for further study by comparing them to marketed drugs using FTIR spectroscopy and the COMPARE analysis from the NCI. Both methods can produce fingerprints and highlight differences between the compounds, classifying the candidates and revealing promising derivatives.
- Published
- 2013