1. Conformational stability of triazolyl functionalized collagen triple helices
- Author
-
Helma Wennemers and Roman S. Erdmann
- Subjects
Chemistry ,Stereochemistry ,Protein Conformation ,Protein Stability ,Collagen helix ,Organic Chemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Triazoles ,Biochemistry ,Protein Structure, Secondary ,Synthetic materials ,Protein structure ,Alkynes ,Drug Discovery ,Click chemistry ,Molecular Medicine ,Surface modification ,Click Chemistry ,Proline ,Conformational stability ,Collagen ,Molecular Biology ,Triple helix - Abstract
Functionalized collagen is attractive for the development of synthetic biomaterials. Herein we present the functionalization of azidoproline containing collagen model peptides with various alkynes using click chemistry. The influence on the stability of the collagen triple helix of the stereochemistry of the introduced triazolyl prolines (4R or 4S), the position of their incorporation (Xaa or Yaa) and the substituents attached to them are shown. The results provide a useful guide for the optimal functionalization of collagen using click chemistry.
- Published
- 2013