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Start Over Author "Erica Chan" Journal bioorganicmedicinal chemistry letters
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1. Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio

Author

Bruce Fahr, Junfa Fan, Duncan Walker, Sravanthi Cheeti, Ute Hoch, Erica Chan, Phuongly Pham, Ingrid C. Choong, Yafan Lu, Iana Serafimova, and David E. Stockett

Subjects
animal structures, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Isonipecotic Acids, Drug Discovery, medicine, Animals, Combinatorial Chemistry Techniques, Isonipecotic acid, Molecular Biology, Oxazoles, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, Cyclin-Dependent Kinase 2, Stereoisomerism, Thiazoles, Enzyme, chemistry, Permeability (electromagnetism), Enzyme inhibitor, biology.protein, Molecular Medicine, Efflux
Abstract

Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032. The enantiomerically pure synthesis and the in vivo profile of analog 20 is described.

Published
2008

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