1. Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line
- Author
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Nguyen Duy Phan, Ashraf M. Omar, Sijia Sun, Juthamart Maneenet, Dya Fita Dibwe, Mao Sato, Surya Kant Kalauni, Naoki Toyooka, Tsutomu Fujii, and Suresh Awale
- Subjects
Molecular Structure ,Plant Extracts ,Organic Chemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Biochemistry ,Antineoplastic Agents, Phytogenic ,Pancreatic Neoplasms ,Cell Line, Tumor ,Drug Discovery ,Abietanes ,Molecular Medicine ,Humans ,Drug Screening Assays, Antitumor ,Molecular Biology ,Abies - Abstract
An ethanolic extract of the stem of Abies spectabilis exhibited strong cytotoxicity against MIA PaCa-2 human pancreatic cancer cells preferentially under nutrient-deprived conditions. Therefore, phytochemical investigation of this bioactive extract was carried out, and that led the isolation of ten compounds (1-10) including a new abietane-type diterpene (1). The structure of the new compound (1) was elucidated by combined spectroscopic techniques, including HRFABMS, NMR and quantum ECD calculation. All the isolated compounds were evaluated for their efficacy against MIA PaCa-2 human pancreatic cancer cell line by employing an anti-austerity strategy. Among the tested compounds, dehydroabietinol (5) displayed the most potent activity with a PC
- Published
- 2022