1. Wake-promoting agents: search for next generation modafinil: part I
- Author
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Patricia A. Messina‐McLaughlin, Yin Guo Lin, Mark A. Ator, Alyssa Reiboldt, Mohamed Iqbal, Greg A. Hostetler, John A. Gruner, Derek Dunn, Sankar Chatterjee, and Edward R. Bacon
- Subjects
Male ,Clinical Biochemistry ,Compound 17 ,Pharmaceutical Science ,Modafinil ,Pharmacology ,Motor Activity ,Biochemistry ,Rats sprague dawley ,Rats, Sprague-Dawley ,Structure-Activity Relationship ,Wakefulness-Promoting Agents ,Drug Discovery ,medicine ,Animals ,Motor activity ,Benzhydryl Compounds ,Wakefulness ,Molecular Biology ,Chemistry ,Organic Chemistry ,Biphenyl Compounds ,Electroencephalography ,Stereoisomerism ,Rats ,Biphenyl compound ,Sprague dawley ,Area Under Curve ,Molecular Medicine ,Retinoic acid 4-hydroxylase ,Central Nervous System Stimulants ,Sleep ,Neuroscience ,psychological phenomena and processes ,Injections, Intraperitoneal ,medicine.drug - Abstract
In search of a next generation molecule to the novel wake promoting agent modafinil, a series of bi-phenyl derived wakefulness enhancing agents (in rat) was developed. From this work, compound 17 has been selected for additional studies.
- Published
- 2011