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Start Over Author "Matthew J. Graneto" Journal bioorganicmedicinal chemistry letters
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1. Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Author

D. J. Rogier, John J. Talley, Jeffery S. Carter, Matthew J. Graneto, Carol M. Koboldt, Yan Zhang, and Karen Seibert

Subjects
Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Isozyme, Sulfone, Prostaglandin-endoperoxide synthase 2, chemistry.chemical_compound, Inhibitory Concentration 50, Drug Discovery, Animals, Sulfones, Molecular Biology, Sulfonyl, chemistry.chemical_classification, biology, Organic Chemistry, Rats, Isoenzymes, Thiazoles, Enzyme, chemistry, Enzyme inhibitor, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, biology.protein, Molecular Medicine, Cyclooxygenase
Abstract

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

Published
1999

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