1. The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands
- Author
-
Lidiya Stavitskaya, Marilyn M. Matthews-Tsourounis, Michael J. Seminerio, Andrew Coop, and Rae R. Matsumoto
- Subjects
Stereochemistry ,Nitrogen ,Clinical Biochemistry ,Sigma receptor ,Pharmaceutical Science ,chemistry.chemical_element ,Ligands ,Biochemistry ,Piperazines ,Article ,Drug Discovery ,parasitic diseases ,Receptors, sigma ,heterocyclic compounds ,Binding site ,Receptor ,Molecular Biology ,Receptors sigma ,Binding Sites ,Chemistry ,organic chemicals ,fungi ,Organic Chemistry ,Sigma ,Sigma ligands ,Chain length ,bacteria ,Molecular Medicine - Abstract
A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the sigma(1) and sigma(2) receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor sigma(1) receptors, while previously studied (2-pyridyl)piperazines favor sigma(2) receptors.
- Published
- 2010