1. First example of an antibody-catalyzed aza Diels-Alder reaction
- Author
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Bing-Hui Yang, Yulin Wu, Ming Yeh, Yong-Yong Ji, Ya-Juan Pan, and Zhen-Dan Shi
- Subjects
Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,chemical and pharmacologic phenomena ,Biochemistry ,Chemical synthesis ,Antibodies ,Catalysis ,Adduct ,chemistry.chemical_compound ,Bridged Bicyclo Compounds ,Drug Discovery ,Animals ,Aza-Diels–Alder reaction ,Octene ,Molecular Biology ,Aza Compounds ,biology ,fungi ,Organic Chemistry ,Serum Albumin, Bovine ,Alkadienes ,Kinetics ,chemistry ,Polyclonal antibodies ,biology.protein ,Molecular Medicine ,Stereoselectivity ,Immunization ,Rabbits ,Hapten ,Haptens - Abstract
Described herein is the synthesis of a hapten of biocyclo[2,2,2]octene 5 designed to mimic the exo transition-state of an aza Diels-Alder reaction. Immunization of rabbits with this hapten provided polyclonal antibodies, Aza-BSA-3, which were used to synthesize adduct 4b in the first reported antibody-catalyzed exo Diels-Alder reaction.
- Published
- 2002