1. Comparing early liver graft function from heart beating and living-donors: A pilot study aiming to identify new biomarkers of liver injury
- Author
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Qi Joy, Yang, Michael, Kluger, Krzysztof, Goryński, Janusz, Pawliszyn, Barbara, Bojko, Ai-Ming, Yu, Keumhan, Noh, Markus, Selzner, Angela, Jerath, Stuart, McCluskey, K Sandy, Pang, and Marcin, Wąsowicz
- Subjects
Adult ,Male ,Pilot Projects ,gamma-Glutamyltransferase ,Middle Aged ,Models, Biological ,Tissue Donors ,Liver Transplantation ,MicroRNAs ,Tranexamic Acid ,Humans ,Metabolomics ,Female ,Androstanols ,Rocuronium ,Biomarkers ,Liver Failure ,Aged - Abstract
The liver and kidney functions of recipients of liver transplantation (LT) surgery with heart beating (HBD, n = 13) or living donors (LD, n = 9) with different cold ischemia times were examined during the neohepatic phase for the elimination of rocuronium bromide (ROC, cleared by liver and kidney) and tranexamic acid (TXA, cleared by kidney). Solid phase micro-extraction and LC-MS/MS was applied to determine the plasma concentrations of ROC and TXA, and creatinine was determined by standard laboratory methods. Metabolomics and the relative expressions of miR-122, miR-148a and γ-glutamyltranspeptidase (GGT), liver injury biomarkers, were also measured. The ROC clearance for HBD was significantly lower than that for LD (0.147 ± 0.052 vs. 0.265 ± 0.148 ml·min
- Published
- 2016