1. Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants
- Author
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Amarendra, Pegu, Sarah E, O'Connell, Stephen D, Schmidt, Sijy, O'Dell, Chloe A, Talana, Lilin, Lai, Jim, Albert, Evan, Anderson, Hamilton, Bennett, Kizzmekia S, Corbett, Britta, Flach, Lisa, Jackson, Brett, Leav, Julie E, Ledgerwood, Catherine J, Luke, Mat, Makowski, Martha C, Nason, Paul C, Roberts, Mario, Roederer, Paulina A, Rebolledo, Christina A, Rostad, Nadine G, Rouphael, Wei, Shi, Lingshu, Wang, Alicia T, Widge, Eun Sung, Yang, John H, Beigel, Barney S, Graham, John R, Mascola, Mehul S, Suthar, Adrian B, McDermott, Nicole A, Doria-Rose, Jae, Arega, Wendy, Buchanan, Mohammed, Elsafy, Binh, Hoang, Rebecca, Lampley, Aparna, Kolhekar, Hyung, Koo, Catherine, Luke, Mamodikoe, Makhene, Seema, Nayak, Rhonda, Pikaart-Tautges, Janie, Russell, Elisa, Sindall, Pratap, Kunwar, Evan J, Anderson, Amer, Bechnak, Mary, Bower, Andres F, Camacho-Gonzalez, Matthew, Collins, Ana, Drobeniuc, Venkata Viswanadh, Edara, Srilatha, Edupuganti, Katharine, Floyd, Theda, Gibson, Cassie M Grimsley, Ackerley, Brandi, Johnson, Satoshi, Kamidani, Carol, Kao, Colleen, Kelley, Hollie, Macenczak, Michele Paine, McCullough, Etza, Peters, Varun K, Phadke, Nadine, Rouphael, Erin, Scherer, Amy, Sherman, Kathy, Stephens, Mehgan, Teherani, Jessica, Traenkner, Juton, Winston, Inci, Yildirim, Lee, Barr, Joyce, Benoit, Barbara, Carste, Joe, Choe, Maya, Dunstan, Roxanne, Erolin, Jana, Ffitch, Colin, Fields, Lisa A, Jackson, Erika, Kiniry, Susan, Lasicka, Stella, Lee, Matthew, Nguyen, Stephanie, Pimienta, Janice, Suyehira, Michael, Witte, Nedim Emil, Altaras, Andrea, Carfi, Marjorie, Hurley, Rolando, Pajon, Wellington, Sun, Tal, Zaks, Rhea N, Coler, Sasha E, Larsen, Kathleen M, Neuzil, Lisa C, Lindesmith, David R, Martinez, Jennifer, Munt, Michael, Mallory, Caitlin, Edwards, Ralph S, Baric, Nina M, Berkowitz, Eli A, Boritz, Kevin, Carlton, Pamela, Costner, Adrian, Creanga, Daniel C, Douek, Martin, Gaudinski, Ingelise, Gordon, LaSonji, Holman, Kwanyee, Leung, Bob C, Lin, Mark K, Louder, Kaitlyn M, Morabito, Laura, Novik, Sarah, O'Connell, Marcelino, Padilla, Phillip A, Swanson, Yi, Zhang, James D, Chappell, Mark R, Denison, Tia, Hughes, Xiaotao, Lu, Andrea J, Pruijssers, Laura J, Stevens, Christine M, Posavad, Michael, Gale, Vineet, Menachery, and Pei-Yong, Shi
- Subjects
Adult ,2019-20 coronavirus outbreak ,COVID-19 Vaccines ,Time Factors ,Adolescent ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunization, Secondary ,Alpha (ethology) ,Cross Reactions ,Antibodies, Viral ,Article ,Young Adult ,Immunogenicity, Vaccine ,Immune system ,Humans ,Medicine ,Beta (finance) ,Aged ,Immune Evasion ,Messenger RNA ,Multidisciplinary ,biology ,SARS-CoV-2 ,business.industry ,Immunogenicity ,Antibody titer ,COVID-19 ,Middle Aged ,Virology ,Antibodies, Neutralizing ,Vaccination ,Immunization ,Immunology ,biology.protein ,Antibody ,business ,2019-nCoV Vaccine mRNA-1273 - Abstract
SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, and the durability of such responses has not been previously reported. Here, we present a comprehensive assessment of the impact of variants B.1.1.7, B.1.351, P.1, B.1.429, and B.1.526 on binding, neutralizing, and ACE2-blocking antibodies elicited by the vaccine mRNA-1273 over seven months. Cross-reactive neutralizing responses were rare after a single dose of mRNA-1273. At the peak of response to the second dose, all subjects had robust responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6 months after the primary series of mRNA-1273. Across all assays, B.1.351 had the greatest impact on antibody recognition, and B.1.1.7 the least. These data complement ongoing studies of clinical protection to inform the potential need for additional boost vaccinations., One-Sentence Summary: Most mRNA-1273 vaccinated individuals maintained binding and functional antibodies against SARS-CoV-2 variants for 6 months.
- Published
- 2021