Author: "Takahashi, Hidetoshi" / Journal: bioscience, biotechnology, and biochemistry - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Takahashi, Hidetoshi"' showing total 7 results

Start Over Author "Takahashi, Hidetoshi" Journal bioscience, biotechnology, and biochemistry

Author: Hashizume, Yuko, Murakane, Tatsuhiko, Koga, Emi, Nomura, Yuki, Kakihara, Yoshito, Fujieda, Ayako, Uchida, Motoyuki, and Takahashi, Hidetoshi
Subjects: Saccharomyces cerevisiae, drug screening, Ste11, genome-wide analysis, c-Abl tyrosine kinase
Published: 2007

Author: TSUCHIYA, Eiko, primary, YUKAWA, Masashi, additional, UENO, Masaru, additional, KIMURA, Ken-ichi, additional, and TAKAHASHI, Hidetoshi, additional
Published: 2010
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Author: CHANKLAN, Ruthada, primary, AIHARA, Eiji, additional, KOGA, Saori, additional, TAKAHASHI, Hidetoshi, additional, MIZUNUMA, Masaki, additional, and MIYAKAWA, Tokichi, additional
Published: 2008
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Author: KITAGAWA, Takao, primary, HASHIZUME, Yuko, additional, MURAKANE, Tatsuhiko, additional, KOGA, Emi, additional, NOMURA, Yuki, additional, KAKIHARA, Yoshito, additional, FUJIEDA, Ayako, additional, UCHIDA, Motoyuki, additional, TAKAHASHI, Hidetoshi, additional, HOSHIDA, Hisashi, additional, and AKADA, Rinji, additional
Published: 2007
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Author: IMAMURA, Yuko, primary, YUKAWA, Masashi, additional, KIMURA, Ken-ichi, additional, TAKAHASHI, Hidetoshi, additional, SUZUKI, Yoshihiro, additional, OJIKA, Makoto, additional, SAKAGAMI, Youji, additional, and TSUCHIYA, Eiko, additional
Published: 2005
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Author: SHITAMUKAI, Atsunori, primary, MIZUNUMA, Masaki, additional, HIRATA, Dai, additional, TAKAHASHI, Hidetoshi, additional, and MIYAKAWA, Tokichi, additional
Published: 2000
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Author: IMAMURA, Yuko, YUKAWA, Masashi, KIMURA, Ken-ichi, TAKAHASHI, Hidetoshi, SUZUKI, Yoshihiro, OJIKA, Makoto, SAKAGAMI, Youji, and TSUCHIYA, Eiko
Abstract: Fredericamycin A (FMA) is an antibiotic product of Streptomyces griseusthat exhibits modest antitumor activity in vivoand in vitro, but, its functions in vivoare poorly understood. We identified this compound as an inducer of G1 arrest in the yeast, Saccharomyces cerevisiae. FMA exhibits an IC50 of 24 nMtowards the growth of a disruptant of multi-drug resistance genes, W303-MLC30, and its cytotoxicity is a function of the time of exposure as well as drug dose. Addition of 0.8 μMof FMA caused aggregation of mitochondria within 10 min of incubation and the drug induced petites at high frequency after 4 h of incubation. rho−cells were about 20 times more resistant to FMA than isogenic rho+cells. Overexpression of topoisomerase I, a previously suggested target of the drug, did not alleviate the sensitivity of the cells to FMA or the aggregation of mitochondria. Our results suggest that mitochondria are the primary target site of FMA.
Published: 2005
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