Search

Your search keyword '"Yasuhiro Kihara"' showing total 1 results
Start Over Author "Yasuhiro Kihara" Journal bioscience, biotechnology, and biochemistry
1 results on '"Yasuhiro Kihara"'

1. Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase

Author

Yasuhiro Kihara, Erina Nishimura, Chisato Kanai, Yoshikazu Kitano, Eriko Suzuki, and Keiji Hasumi

Subjects
Organic Chemistry, General Medicine, Molecular Biology, Applied Microbiology and Biotechnology, Biochemistry, Analytical Chemistry, Biotechnology
Abstract

Soluble epoxide hydrolase (EC 3.3.2.10) is a key enzyme in the regulation of inflammation and metabolism, whereas, the role of its N-terminal phosphatase activity (N-phos) has been poorly understood because of a lack of selective inhibitors. Here we report 4-aminobenzoic (Ki 15.3 µm) and 3-amino-4-hydroxy benzoic acid (Ki 11.7 µm) as selective competitive inhibitors of N-phos.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results