Search

We investigated the anti-stress effect of rosemary (Rosmarinus officinalis L.) leaf extract (RLE) on restraint-stressed mice and found that RLE alleviated decreases in the number of intestinal goblet cells and amount of hepatic triglycerides. It also decreased the immobility time in the forced-swimming test and activation of microglia in the brain, suggesting that RLE has beneficial effects on stress-induced dysfunctions. [ABSTRACT FROM AUTHOR]

Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism. Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice. Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice. [ABSTRACT FROM AUTHOR]

The article discusses a study which examines the effect of edible rhizome of Nelumbo nucifera on the protection against hepatic injury from non alcoholic fatty liver disease (NAFLD) in obese diabetic mice. The presence of polyphenolic compounds proanthocyanidins in lotus roots along with its health promoting properties is also described. The suppression of lipogenic enzyme, inflammatory genes and elevation of adiponectin serum level which has protective effect against NAFLD is reported.

The article presents a study which identifies the physiologically active substances responsible for alleviating the lipid abnormalities in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. It examines the effects of a hot water extract and fractional extracts from rabbiteye blueberry leaves (BBL) on lipid metabolism. Results show that BBL extracts exerted hypolipidemic effects on OLETF rats and suggests that an infusion of BBL can be useful as a dietary hypolipidemic component.

The article presents a study which examines the effects of T0901317 (T0) on the lymphatic absorption and deposition of plant sterols in stroke-prone spontaneously hypertensive rats (SHRSPs) and Wistar rats. The study examines four week-old male Wister rats and SHRSPs fed with purified diet containing 10% lard. Result suggests that the plant sterol deposition in SHRSPs was not caused by increased absorption of plant sterols.

The article presents a study on the effect of blueberry, Vaccinium ashei reade, leaves (BBL) on lipid metabolism in obese rats. It was found that levels of serum lipids and C-reactive protein were lowered and the hepatic triglyceride accumulation was alleviated after feeding rats with BBL. Results suggest the use of BBL as a dietary hypolipidemic component, with its hypolipidemic effect attributed to a reduction of lipogenesis and enhancement of lipolysis in the liver.

The article focuses on the specific action of the conjugated linoleic acid (CLA) isomer against hyperlipidemia and obesity in obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. In this study, the author have shown that dietary CLA isomer, as equated with alinoleic acid-rich control diet, significantly inhibited abdominal adipose tissue and lipids in the liver of OLETF rats.

The article cites a study that examined the effect of consumption of pork-liver protein hydrolysate (PLH) on body fat accumulation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. OLETF rats are used as a non-insulin-dependent diabetes mellitus model and Long-Evans Tokushima Otsuka rats as a control. In the OLETF rats, dietary PLH significantly reduced the growth and weight of fat pad including perirenal and epididymal adipose tissues.

Explores the effects of dietary tea catechins on visceral fat accumulation and triacylglycerol metabolism in rats to reveal the precise mechanisms of the reduction of visceral fat deposition by tea catechins. Comparison of the effect of heat-treated tea catechins on the parameters with that of tea catechins; Indication that dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats.

Investigates the purification of conjugated linoleic acid isomers through a process including lipase-catalyzed selective esterification. Effect of the urea adduct fractionation.

The article presents a study which examines the impact of soybean-derived phospholipids, PIPS NAGASE (PIPS), to an obese Zucker rats. The study made use of an enzymatic transphophatidylation method to prepare PIPs. It says that the concentration of hepatic triglyceride and hepatic injury maker was analyzed to examine the dietary PIPS effect. The result of the study shows the reduction of risk of life-style-related diseases in rats which reveals that PIPS was an effective dietary component.

The article focuses on a study which examines the physiological effect of the sulfated polysaccharide porphyran from an edible red alga in human hepatoma HepG2 cells. It mentions that through cellular lipid synthesis, the sulfated polysaccharide porphyran has lessened the apolipoprotein B100 (apoB100) in human hepatoma HepG2 cells. Finding suggests that sulfated polysaccharide porphyran can be used as a dietary hypolipidemic component.

The article discusses a study on the effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo. Blueberry leaf showed a strong inhibitory effect on angiotensin-converting enzyme in vitro. The feeding of blueberry leaf suppressed the development of essential hypertension in spontaneously hypertensive rats in vivo.

Studies the physiological effects of 9cis,11trans,l3cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, in human hepatoma HepG2 cells. Indication that 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA); Decrease of uptake of [sup 14]C-oleate into newly synthesized cellular triacylglycerol by 9c,11t,13c-CLNA more than by alpha-LNA treatment; First study to show the hypolipidemic effect of 9c,11t,13c-CLNA.