1. Association between selenium levels and oesophageal adenocarcinoma risk: evidence from a meta-analysis
- Author
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Ying Du, Ning Mao, Liangbo Hu, Tao Xiong, Chao Li, Lihong Huang, and Bin Hong
- Subjects
Male ,medicine.medical_specialty ,Esophageal Neoplasms ,Biophysics ,chemistry.chemical_element ,Adenocarcinoma ,Biochemistry ,Gastroenterology ,Selenium ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Molecular Biology ,Aged ,Original Paper ,business.industry ,Case-control study ,Cell Biology ,Publication bias ,Middle Aged ,Original Papers ,Confidence interval ,meta-analysis ,chemistry ,Case-Control Studies ,030220 oncology & carcinogenesis ,Meta-analysis ,Relative risk ,oesophageal adenocarcinoma ,Female ,business ,Cohort study - Abstract
Quantification of the association between selenium and risk of oesophageal adenocarcinoma (OAC) is still conflicting. The purpose of this meta-analysis is to explore the relationship between selenium levels and OAC risk. PubMed and Web of Knowledge were searched for the related articles. Pooled relative risks (RRs) with 95% confidence intervals (CIs) from random effects models were calculated. Sensitivity analysis and publication bias were conducted. Dose–response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. Five articles involving 748 OAC cases were included in this meta-analysis. Pooled results suggest that higher selenium level was not significantly associated with the risk of OAC (summary RRs=1.08, 95% CIs=0.84–1.39, I2=0%). Besides, no significant association was found in case-control studies (summary RRs=1.13, 95% CIs=0.84–1.52, I2=0%) or cohort studies (summary RRs=0.99, 95% CIs=0.55–1.78, I2=32.6%). A linear dose–response relationship was attested that an increase in dietary selenium intake of 10 μg/day is marginally associated with 1% increase in the risk of developing OAC (summary RRs=1.01, 95% CIs=0.99–1.03), but not statistically significant. No publication bias was found. In conclusion, our analysis indicated that a higher selenium level was not significantly associated with the risk of OAC. The relevant further studies are warranted.
- Published
- 2016