1. Association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with lung cancer risk: an updated meta-analysis
- Author
-
Xiang-Hua Ye, Wen-Ping Zhang, and Xiao-Feng He
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,Bayesian probability ,CYP1A1 ,Biophysics ,Biochemistry ,polymorphism ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Credibility ,Cytochrome P-450 CYP1A1 ,Humans ,Medicine ,Genetic Predisposition to Disease ,Lung cancer ,Molecular Biology ,Research Articles ,Glutathione Transferase ,Cancer ,business.industry ,Cell Biology ,medicine.disease ,Meta-analysis ,030104 developmental biology ,Increased risk ,Systematic review ,030220 oncology & carcinogenesis ,Mutation ,Epigenetics ,business ,Polymorphism, Restriction Fragment Length ,GSTM1 - Abstract
Background: Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 (GSTM1) present/null and cytochrome P4501A1 (CYP1A1) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory. Two previous meta-analyses have been reported on the issue in 2011 and 2014. However, several new articles since then have been published. In addition, their meta-analyses did not valuate the credibility of significantly positive results. Objectives: We performed an updated meta-analysis to solve the controversy following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Methods: False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and the Venice criteria were used to verify the credibility of meta-analyses. Results: Twenty-three publications including 5734 LC cases and 7066 controls met the inclusion criteria in the present study. A significantly increased risk of LC was found in overall analysis, Asians and Indians. However, all positive results were considered as ‘less-credible’ when we used the Venice criteria, FPRP, and BFDP test to assess the credibility of the positive results. Conclusion: These positive findings should be interpreted with caution and results indicate that significant associations may be less-credible, there are no significantly increased LC risk between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms.
- Published
- 2020