1. Three-dimensional drivable optrode array for high-resolution neural stimulations and recordings in multiple brain regions.
- Author
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Wang, Ming-Hao, Gu, Xiao-Wei, Ji, Bo-Wen, Wang, Long-Chun, Guo, Zhe-Jun, Yang, Bin, Wang, Xiao-Lin, Li, Cheng-Yu, and Liu, Jing-Quan
- Subjects
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NEURAL stimulation , *NEURAL circuitry , *NERVOUS system , *SEMICONDUCTOR lasers , *NEUROLOGICAL disorders , *PREMOTOR cortex - Abstract
Abstract The brain-computer interface (BCI) devices are of prime important for study of nervous system as well as diagnosis and treatment of neurological disorders. To meet the needs of the BCI devices in high-density integration and multi-functionalization, 3-dimensional (3D) drivable optrode array with laser diodes (LDs) coupled waveguides was developed. The unique device realizes the 3D integration of the optrodes and avoids fiber tangle and tissue heating by adopting LD coupled waveguide structure. Besides, the postoperative position adjustment of the optrode array was achieved by integrating with a 3D printed micro-drive. Most importantly, high-resolution neural stimulations and recordings were achieved for study of working memory related neural circuits in four brain regions of mice including prelimbic cortex (PrL), mediodorsal thalamic nucleus (MD), dorsal medial caudate nucleus (dmCP) and posterior motor cortex 2 (pM2). The results indicate that this novel device is promising for the research of complex neural networks. Highlights • The design and in-vivo use of a novel 3D drivable optrode array was described. • Fiber tangle and tissue heating was avoided by adopting LD coupled waveguide. • Postoperative position adjustment was achieved by integrating with micro-drive. • High-resolution neural manipulation was achieved in four brain regions of mice. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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