1. Single injection of CD8+ T lymphocytes derived from hematopoietic stem cells – Mathematical and numerical insights.
- Author
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Korpusik, Adam and Kolev, Mikhail
- Subjects
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HEMATOPOIETIC stem cells , *MATHEMATICAL models , *THERAPEUTICS , *HIV infections , *CD8 antigen , *CYTOTOXIC T cells , *IMMUNE response - Abstract
Recently, hematopoietic stem cell (HSC) based therapy is being discussed as a possible treatment for HIV infection. The main advantage of this approach is that it limits the immune impairing effect of infection by introducing an independent influx of antigen-specific cytotoxic T lymphocytes (CTL). In this paper, we present a mathematical approach to predict the dynamics of HSC based therapy. We use a modification of a basic mathematical model for virus induced impairment of help to study how virus – immune system dynamics can be influenced by a single injection of CD8+ T lymphocytes derived from hematopoietic stem cells. Our mathematical and numerical results indicate that a single, large enough dose of genetically derived CTL may lead to restoration of the cellular immune response and result in long-term control of infection. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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