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1. A novel DAD type and folic acid conjugated fluorescent monomer as a targeting probe for imaging of folate receptor overexpressed cells.

Author

Ekiz Kanik F, Ag D, Seleci M, Barlas FB, Kesik M, Hizalan G, Akpinar H, Timur S, and Toppare L

Subjects
Diagnostic Imaging, Folate Receptor 1 biosynthesis, HeLa Cells, Humans, Magnetic Resonance Spectroscopy, Microscopy, Fluorescence, Nanoparticles chemistry, Spectroscopy, Fourier Transform Infrared, Fluorescent Dyes chemistry, Folate Receptor 1 isolation & purification, Folic Acid analogs & derivatives, Folic Acid chemistry, Gene Expression Regulation, Triazoles chemistry
Abstract

We describe a modification and post-functionalization technique for a donor-acceptor-donor type monomer; 6-(4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2H-benzo[d][1,2, 3]triazol-2-yl)hexan-1-amine. Folic acid was attached to the fluorescent structure. The conjugation was confirmed via NMR and Fourier transform infrared analyses. Cytotoxicity was investigated and the comparison of association of targeted monomeric structures in tumor cells was monitored via fluorescence microscopy., (© 2014 American Institute of Chemical Engineers.)

Published
2014
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