1. Measuring the exposome in bipolar disorder.
- Author
-
Ercis, Mete, Ozerdem, Aysegul, Veldic, Marin, Singh, Balwinder, Coombes, Brandon J., Biernacka, Joanna M., Lazaridis, Konstantinos N., and Frye, Mark A.
- Subjects
- *
LIQUID chromatography-mass spectrometry , *GENOTYPE-environment interaction , *BIOMACROMOLECULES , *CHEMICAL adducts , *BIPOLAR disorder , *DNA adducts - Abstract
The article discusses the importance of measuring the exposome in bipolar disorder research. While bipolar disorder has a genetic component, genetic variants only explain a small portion of the disease's variation and risk. Environmental exposures, both modifiable and non-modifiable, play a significant role in the development of bipolar disorder. The exposome concept, introduced in 2005, emphasizes the need to assess all environmental exposures an individual encounters throughout their life. Measuring the exposome is challenging but can be achieved through emerging technologies and multi-omics investigation. Understanding an individual's exposome composition can provide insights into the gene-environment interplay and lead to breakthrough discoveries in bipolar disorder research. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF