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Your search keyword '"Nikethamide pharmacology"' showing total 6 results
Start Over Descriptor "Nikethamide pharmacology" Journal biulleten eksperimentalnoi biologii i meditsiny
6 results on '"Nikethamide pharmacology"'

1. [Disturbed functioning of enzyme systems of microsomal oxidation, glucuro-, and glutathione conjugation of xenobiotics in the liver of rats intoxicated by deoxycholate and their correction].

Author

Bushma MI, Legon'kova LF, Zverinskiĭ IV, and Vasil'ev AV

Subjects
Animals, Chemical and Drug Induced Liver Injury enzymology, Chemical and Drug Induced Liver Injury etiology, Cholagogues and Choleretics pharmacology, Microsomes, Liver enzymology, Nikethamide pharmacology, Rats, S-Adenosylmethionine pharmacology, Ursodeoxycholic Acid pharmacology, Vitamin E pharmacology, Chemical and Drug Induced Liver Injury metabolism, Deoxycholic Acid, Glucuronides metabolism, Glutathione metabolism, Microsomes, Liver metabolism, Xenobiotics metabolism
Published
2000

2. [Disturbed functioning of enzyme systems of the microsomal oxidation, glucuro- and glutathione conjugation of xenobiotics in the liver of rats intoxicated by deoxycholate and their correction].

Author

Bushma MI, Legon'kova LF, Zverinskiĭ IV, and Vasil'ev AV

Subjects
Animals, Cholagogues and Choleretics pharmacology, Cholestasis chemically induced, Cholestasis metabolism, Deoxycholic Acid toxicity, Male, Microsomes, Liver enzymology, Nikethamide pharmacology, Rats, S-Adenosylmethionine pharmacology, Ursodeoxycholic Acid pharmacology, Vitamin E pharmacology, Cholestasis drug therapy, Deoxycholic Acid metabolism, Glucuronates metabolism, Glutathione metabolism, Microsomes, Liver drug effects, Xenobiotics metabolism
Published
2000

3. [Inhibition of the antioxidant protection, microsomal oxidation, and xenobiotic glucuroconjugation in rats with cholestasis and their regulation].

Author

Bushma MI, Legon'kova LF, Zverinskiĭ IV, Khomich TI, Karpovich VE, Konovalenko OV, Karaedova LM, and Lashak LK

Subjects
Animals, Cholestasis blood, Liver drug effects, Liver enzymology, Liver metabolism, Male, Microsomes, Liver drug effects, Microsomes, Liver enzymology, Mixed Function Oxygenases metabolism, Nikethamide pharmacology, Oxidation-Reduction, Phosphatidylcholines pharmacology, Rats, S-Adenosylmethionine pharmacology, Ursodeoxycholic Acid pharmacology, Antioxidants metabolism, Cholestasis metabolism, Glucuronates metabolism, Microsomes, Liver metabolism, Xenobiotics metabolism
Published
1999

4. [A comparative study of the effects of nicotinamide and diethylnicotinamid on hepatic monooxygenase, glucuronyl and glutathione conjugating systems].

Author

Legon'kova LF, Bushma MI, and Lukienko PI

Subjects
Animals, Chloral Hydrate pharmacology, Cytochrome P-450 Enzyme System metabolism, Glucuronosyltransferase metabolism, Glutathione Transferase metabolism, Liver drug effects, Liver enzymology, Male, Microsomes, Liver enzymology, Oxygenases metabolism, Rats, Sleep drug effects, Liver metabolism, Niacinamide pharmacology, Nikethamide pharmacology
Abstract

The nicotinamide administration to rats (50 mg/kg, subcutaneously, over 5 days) increased the concentration of liver cytochrome b5, the activities of cytosol and microsomal glutathione S-transferase, UDP-glucuronosyltransferase and urinary excretion of bound glucuronic acid by 26.7, 33.1, 33.3, 53.0 and 31.0%, respectively. The chloral hydrate-induced sleep time in mice was reduced by 65%. Under similar experimental conditions the administration of equimolar amounts of diethylamide of nicotinic acid (75 mg/kg) exerted a more pronounced enzyme-stimulating effect. The cytochrome P-450 concentration, the activities of cytosol and microsomal glutathione S-transferase, UDP-glucuronosyltransferase as well as the sulphobromophthalein elimination from blood plasma and urinary excretion of bound glucuronic acid were increased by 37.0, 33.1, 54.6, 80.5, 24.5 and 49.0%, whereas the chloral hydrate-induced sleep time decreased by 75%. The nicotinamide and diethylamide of nicotinic acid stimulating effects on xenobiotic biotransformation in rat liver are assumed to be due to enhanced NADPH, glutathione and UDP-glucuronic acid biosynthesis as well as their antioxidant properties.

Published
1990

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